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Eosinophilia–myalgia syndrome is a rare, sometimes fatal neurological condition linked to the ingestion of the dietary supplement L-tryptophan. [1] [2] The risk of developing EMS increases with larger doses of tryptophan and increasing age. [3]
A cancer vaccine, or oncovaccine, is a vaccine that either treats existing cancer or prevents development of cancer. [1] Vaccines that treat existing cancer are known as therapeutic cancer vaccines or tumor antigen vaccines. Some of the vaccines are "autologous", being prepared from samples taken from the patient, and are specific to that patient.
Tryptophan ball and stick model spinning. Tryptophan (symbol Trp or W) [3] is an α-amino acid that is used in the biosynthesis of proteins.Tryptophan contains an α-amino group, an α-carboxylic acid group, and a side chain indole, making it a polar molecule with a non-polar aromatic beta carbon substituent.
[8]: 327–328 Multiple epidemiological studies [7] [9] [10] traced an outbreak of eosinophilia-myalgia syndrome (EMS) to L-tryptophan supplied by Showa Denko, which resulted in 37 deaths. [11] [12] It was further hypothesized that one or more trace impurities produced during the manufacture of tryptophan may have been responsible for the EMS ...
Scientific advances helped avert 4.1 million deaths from cancer in the 30 years between 1991 and 2021 according to a new report, but the disease continues to be a public health challenge. The ...
Personalized mRNA cancer vaccine therapy is a therapy that uses a personalized cancer vaccine based on mRNA vaccine technology to target existing tumors in patients. As of 2024, number of mRNA cancer vaccines are in clinical trials, of which many are personalized therapies based on engineering mRNA-mediated immune response that targets the patient's particular strain of cancer cells.
1-Methyltryptophan is a chemical compound that is an inhibitor of the tryptophan catabolic enzyme indoleamine 2,3-dioxygenase (IDO or INDO EC 1.13.11.52). [1] It is a chiral compound that can exist as both D - and L-enantiomers. The L-isomer (L-1MT) inhibits IDO weakly but also serves as an enzyme substrate.
rhesus rotavirus vaccine-tetravalent (RotaShield) 1999 US Withdrawn due to risk of intussusception. [47] Rimonabant (Acomplia) 2008 Worldwide Risk of severe depression and suicide. [14] Rofecoxib 2004 Worldwide Withdrawn by Merck & Co. Risk of myocardial infarction and stroke. [2] Rosiglitazone (Avandia) 2010 Europe Risk of heart attacks and death.