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BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B , while the protein is more formally known as serine/threonine-protein kinase B-Raf .
V600E is a mutation of the BRAF gene in which valine (V) is substituted by glutamic acid (E) at amino acid 600. [1] [2] It is a driver mutation in a proportion of certain diagnoses, including melanoma, [3] [4] hairy cell leukemia, [5] [6] papillary thyroid carcinoma, [7] [8] colorectal cancer, [9] non-small-cell lung cancer, [10] [11] Langerhans cell histiocytosis, [12] Erdheim–Chester ...
Imperforate lacrimal punctum is a congenital disorder of dogs involving the lack of an opening to the nasolacrimal duct (tear duct) in the conjunctiva. [63] Exophthalmos is a normal condition in brachycephalic (short nosed) dog breeds because of the shallow orbit. However, it can lead to keratitis secondary to exposure of the cornea. [63]
Some abnormal behaviours may be related to environmental conditions (e.g. captive housing) whereas others may be due to medical conditions. The list does not include behaviours in animals that are genetically modified to express abnormal behaviour (e.g. reeler mice). A polar bear performing stereotyped pacing.
The Duffy antigen/chemokine receptor gene (gp-Fy; CD234) is located on the long arm of chromosome 1 (1.q22-1.q23) and was cloned in 1993. [6] The gene was first localised to chromosome 1 in 1968, and was the first blood system antigen to be localised.
Some of the blood products are from dogs like Augustus, a 55-pound Belgian Malinois whose owner signed him up to donate blood at a canine community blood bank, which is modeled after the human ...
The disorder was first described by Egeberg in 1965. [5] The causes of acquired antithrombin deficiency are easier to find than the hereditary deficiency. [3] The prevalence of antithrombin deficiency is estimated at ~0.02 to 0.2% of the general population, and 1-5% of patients with venous thromboembolism. [6]
Skin conditions in dogs are very common, so it's important to recognize the symptoms and understand the factors that cause them. Dr. Rebecca MacMillan, a vet with over 15 years of experience, says ...