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[1] [4] Complications can include swelling of the brain or lungs, seizures, low blood sugar, or cardiac arrest. [1] While usually due to aspirin, other possible causes include oil of wintergreen and bismuth subsalicylate. [2] Excess doses can be either on purpose or accidental. [1] Small amounts of oil of wintergreen can be toxic. [2]
Aspirin is non-selective and irreversibly inhibits both forms [4] (but is weakly more selective for COX-1 [5]). It does so by acetylating the hydroxyl of a serine residue at the 530 amino acid position. [6] Normally COX produces prostaglandins, most of which are pro-inflammatory, and thromboxanes, which promote clotting.
Aspirin helps prevent blood clots from forming, which is the leading cause of heart attack and stroke, but the drug also carries a risk of bleeding. That risk can outweigh aspirin’s benefits in ...
Diseases: Coagulation, platelet and blood vessel diseases or deficiencies can increase bruising due to more bleeding. Location: More extensive vascularity causes more bleeding. Areas such as the arms, knees, shins and the facial area are especially common bruise sites. Forces: Greater striking forces cause greater bruising.
For a small number of people, taking aspirin can result in symptoms including hives, swelling, and headache. [206] Aspirin can exacerbate symptoms among those with chronic hives, or create acute symptoms of hives. [207] These responses can be due to allergic reactions to aspirin, or more often due to its effect of inhibiting the COX-1 enzyme.
There is controversy regarding the cause of brachioradial pruritus: is it caused by a nerve compression in the cervical spine or is it caused by a prolonged exposure to sunlight? In many patients, itching of the arms or shoulders is seasonal. Some patients reported neck pain. [citation needed] BRP can be linked to the thyroid. [citation needed]
Salicylate overdose can occur in people without salicylate sensitivity, and can be deadly if untreated. For more information, see aspirin poisoning . Salicylates are derivatives of salicylic acid that occur naturally in plants and serve as a natural immune hormone and preservative , protecting the plants against diseases , insects , fungi , and ...
Aspirin-exacerbated respiratory disease (AERD), also called NSAID-exacerbated respiratory disease (N-ERD) or historically aspirin-induced asthma and Samter's Triad, is a long-term disease defined by three simultaneous symptoms: asthma, chronic rhinosinusitis with nasal polyps, and intolerance of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs).