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Testosterone levels with 100 to 300 mg/day oral cyproterone acetate and low-dose oral estrogen in men. [160] The estrogen used was 0.1 mg/day diethylstilbestrol (DES), [160] which has been described as an "extremely low" dosage. [87] Levels of testosterone were decreased by about 95% with the combination and by about 61% with cyproterone ...
Testosterone replacement therapy works by increasing the amount of testosterone in your system. You’ll take synthetic testosterone to make up for low levels of the natural hormone in your body.
Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an antiandrogen and progestin medication used in the treatment of androgen-dependent conditions such as acne, excessive body hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender individuals ...
[2] [27] In addition, while a 60 mg dose has no effect on testosterone levels in men, this dose does measurably increase testosterone levels in prepubertal boys and women. [27] The oral bioavailability of testosterone in young women after a single 25 mg dose was found to be 3.6 ± 2.5%. [29]
[23] [24] [25] However, when given to men with hypogonadism in the short- and medium-term, testosterone replacement therapy does not increase the risk of cardiovascular events (including strokes and heart attacks and other heart diseases). [2] The long-term safety of the therapy is not known yet. [26] [27]
[7] [110] In one study, 120 to 160 mg/day megestrol acetate suppressed testosterone levels in men by 72%. [104] However, a recovery or "escape" of testosterone levels, gradually returning to near-normal values, has been observed in most men after 2 to 6 months of megestrol acetate therapy, and this has limited the usefulness of the medication.
Nandrolone decanoate has been studied in the treatment of bone loss in men, but in contrast to testosterone esters, was found to be ineffective. [ 55 ] [ 56 ] In short-term (6- to 8-week) studies in healthy male bodybuilders, nandrolone decanoate did not alter bone mineral density.
Testosterone enanthate is used primarily in androgen replacement therapy. [4] [15] It is the most widely used form of testosterone in androgen replacement therapy. [4]The medication is specifically approved, in the United States, for the treatment of hypogonadism in men, delayed puberty in boys, and breast cancer in women. [16]