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There is no level of BNP that perfectly separates patients with and without heart failure. [14]In screening for congenital heart disease in pediatric patients, an NT-proBNP cut-off value of 91 pg/mL could differentiate an acyanotic heart disease (ACNHD) patient from a healthy patient with a sensitivity of 84% and specificity of 42%. [15]
BNP is synthesized as a 134-amino acid preprohormone (preproBNP), encoded by the human gene NPPB. Removal of the 26-residue N-terminal signal peptide generates the prohormone, proBNP, which is stored intracellularly as an O-linked glycoprotein; proBNP is subsequently cleaved between arginine-102 and serine-103 by a specific convertase (probably furin or corin) into NT-proBNP and the ...
The false positive rate (FPR) is the proportion of all negatives that still yield positive test outcomes, i.e., the conditional probability of a positive test result given an event that was not present. The false positive rate is equal to the significance level. The specificity of the test is equal to 1 minus the false positive rate.
One consequence of the high false positive rate in the US is that, in any 10-year period, half of the American women screened receive a false positive mammogram. False positive mammograms are costly, with over $100 million spent annually in the U.S. on follow-up testing and treatment. They also cause women unneeded anxiety. As a result of the ...
STRIDE is a model for identifying computer security threats [1] developed by Praerit Garg and Loren Kohnfelder at Microsoft. [2] It provides a mnemonic for security threats in six categories. [3] The threats are: Spoofing; Tampering; Repudiation; Information disclosure (privacy breach or data leak) Denial of service; Elevation of privilege [4]
The biological half-life of BNP, however, is twice as long as that of ANP, and that of NT-proBNP is even longer, making these peptides better choices than ANP for diagnostic blood testing. In addition to the mammalian natriuretic peptides (ANP, BNP , CNP ), other natriuretic peptides with similar structure and properties have been isolated ...
A cybersecurity regulation comprises directives that safeguard information technology and computer systems with the purpose of forcing companies and organizations to protect their systems and information from cyberattacks like viruses, worms, Trojan horses, phishing, denial of service (DOS) attacks, unauthorized access (stealing intellectual property or confidential information) and control ...
PEAPv0/EAP-MSCHAPv2 is the most common form of PEAP in use, and what is usually referred to as PEAP. The inner authentication protocol is Microsoft's Challenge Handshake Authentication Protocol, meaning it allows authentication to databases that support the MS-CHAPv2 format, including Microsoft NT and Microsoft Active Directory.