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However, tolerance to psilocybin is a well understood concept, with repeatedly higher doses being needed in order to achieve the same effect, due to the down regulation of 5HT2A receptors. [6] There is also documented cross-tolerance between psilocybin and LSD, meaning that a higher dose of these substances is needed to get the same effect when ...
The entourage effect is a hypothesis that cannabis compounds other than tetrahydrocannabinol (THC) act synergistically with it to modulate the overall psychoactive effects of the plant. [ 1 ] [ 2 ] The effect has also been applied in the case of psilocybin mushrooms , with other compounds besides psilocybin having been hypothesized to also ...
Cannabis plants vary widely, with different strains producing dynamic balances of cannabinoids (THC, CBD, etc.) and yielding markedly different effects. Popular strains are often hybrids of C. sativa and C. indica. The medicinal effects of cannabis are widely studied, and are active topics of research both at universities and private research ...
Effects include euphoria, hallucinations, changes in perception, a distorted sense of time, [23] and perceived spiritual experiences. It can also cause adverse reactions such as nausea and panic attacks. Its effects depend on set and setting and one's expectations. [11] [24] Psilocybin is a prodrug of psilocin. [18]
Lean or purple drank (known by numerous local and street names) is a polysubstance drink used as a recreational drug. It is prepared by mixing prescription-grade cough or cold syrup containing an opioid drug and an anti-histamine drug with a soft drink and sometimes hard candy .
Psilocybe cubensis, commonly known as the magic mushroom, shroom, golden halo, golden teacher, cube, or gold cap, is a species of psilocybin mushroom of moderate potency whose principal active compounds are psilocybin and psilocin.
2C-B (4-bromo-2,5-dimethoxyphenethylamine), also known as Nexus, is a synthetic psychedelic drug of the 2C family, mainly used as a recreational drug. [2] [1] [4] It was first synthesized by Alexander Shulgin in 1974 for use in psychotherapy.
The effects last for two to six hours, depending on the amount used. At high doses, mental effects can include anxiety, delusions (including ideas of reference), hallucinations, panic, paranoia, and psychosis. There is a strong relation between cannabis use and the risk of psychosis, though the direction of causality is debated.