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The mission of the Multiple Myeloma Research Consortium (MMRC) is to champion collaboration with and integration across academia and industry and to focus on speed and innovation to bring the most promising multiple myeloma treatments to patients faster.
MGUS is a relatively stable condition afflicting 3% of people aged 50 and 5% of people aged 70; it progresses to multiple myeloma at a rate of 0.5–1% cases per year; smoldering multiple myeloma does so at a rate of 10% per year for the first 5 years, but then falls off sharply to 3% per year for the next 5 years and thereafter to 1% per year.
Uses: M-protein level in the blood is standard of care and is used for almost all patients with multiple myeloma. Patient-specific assays are still generally only used in research protocols. Patient-specific assays are still generally only used in research protocols.
One or more somatic mutations otherwise found in patients with myeloid neoplasms detected in bone marrow or peripheral blood cells with an allele burden of ≥ 2%; Persistent cytopenia (≥ 4 months) in one or more peripheral blood cell lineages; Diagnostic criteria of myeloid neoplasm not fulfilled
Further and more rapid evolution causes the overtly malignant stage of multiple myeloma and can subsequently lead to the extremely malignant stage of secondary plasma cell leukemia. [1] [2] [3] Thus, some patients with smouldering myeloma progress to multiple myeloma and plasma cell leukemia. Smouldering myeloma, however, is not a malignant ...
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The IMF was founded in 1990 by Brian Novis, who was diagnosed with multiple myeloma at age 33, his wife Susie Novis, and his physician Brian G.M. Durie.. Brian Novis died of myeloma in 1992, but the IMF's work continues with Susie Novis serving as President and Durie as Chair of the Board of Directors.
Serum protein electrophoresis showing a paraprotein (spike/peak in the gamma zone) in a patient with multiple myeloma.. A myeloma protein is an abnormal antibody (immunoglobulin) or (more often) a fragment thereof, such as an immunoglobulin light chain, that is produced in excess by an abnormal monoclonal proliferation of plasma cells, typically in multiple myeloma or Monoclonal gammopathy of ...
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