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However, several regions of the mRNA are usually not translated into protein, including the 5' and 3' UTRs. Although they are called untranslated regions, and do not form the protein-coding region of the gene, uORFs located within the 5' UTR can be translated into peptides. [1] The 5' UTR is upstream from the coding sequence. Within the 5' UTR ...
UTRdb and UTRsite; Content; Description: sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs: Organisms: Eukaryotes: Contact; Laboratory
The strict regulation of translation in both space and time is in part governed by cis-regulatory elements located in 5′ mRNA transcript leaders (TLs) and 3′ untranslated regions (UTRs). Due to their role in translation initiation, mRNA 5′ transcript leaders (TLs) strongly influence protein expression.
The 5′ untranslated region (also known as 5′ UTR, leader sequence, transcript leader, or leader RNA) is the region of a messenger RNA (mRNA) that is directly upstream from the initiation codon. This region is important for the regulation of translation of a transcript by differing mechanisms in viruses , prokaryotes and eukaryotes .
In molecular genetics, the three prime untranslated region (3′-UTR) is the section of messenger RNA (mRNA) that immediately follows the translation termination codon. The 3′-UTR often contains regulatory regions that post-transcriptionally influence gene expression .
Poliovirus genome, including an IRES.. IRES elements are most commonly found in the 5' untranslated region, but may also occur elsewhere in mRNAs.The mRNA of viruses of the Dicistroviridae family possess two open reading frames (ORFs), and translation of each is directed by a distinct IRES.
The capsid-coding hairpin region (cHP) actually lies in the ORF of the viral genome and is followed by the 5'CS (conserved sequence), which forms another long-range RNA-RNA interaction with the 3' UTR (3'CS). [5] The cHP aids in the start codon recognition and viral replication.
An upstream open reading frame (uORF) is an open reading frame (ORF) within the 5' untranslated region (5'UTR) of an mRNA. uORFs can regulate eukaryotic gene expression. [1] [2] Translation of the uORF typically inhibits downstream expression of the primary ORF. However, in some genes such as yeast GCN4, translation of specific uORFs may ...