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NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)]. [5] [6] SIRT3 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein.
Unlike other known protein deacetylases, which simply hydrolyze acetyl-lysine residues, the sirtuin-mediated deacetylation reaction couples lysine deacetylation to NAD+ hydrolysis. [12] This hydrolysis yields O-acetyl-ADP- ribose , the deacetylated substrate and nicotinamide , which is an inhibitor of sirtuin activity itself.
It was the first-discovered member of the Sirtuin protein family and it is highly conserved, with homologs found in organisms ranging from humans to bacteria [16] and archaea. [12] It interacts with a variety of protein substrates, but does not exhibit strong affinity for DNA, chromatin, or other silencer-binding factors. [ 12 ]
A peptide microarray (also commonly known as peptide chip or peptide epitope microarray) is a collection of peptides displayed on a solid surface, usually a glass or plastic chip. Peptide chips are used by scientists in biology, medicine and pharmacology to study binding properties and functionality and kinetics of protein-protein interactions ...
The air fried chips are said to have 30% less fat than the regular Kettle Brand sea salt chips, thanks to their air-fried finish. When checking the back of the bag, I saw the two ingredients ...
Sirtuin-activating compounds (STAC) are chemical compounds having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. They are caloric restriction mimetic compounds that may be helpful in treating various aging -related diseases.
After testing nine different salt and vinegar chips, including Cape Cod, Lay's, Wise, Kettle Brand, Utz and more, we've decided on the best brand of all time.
Sirtris Pharmaceuticals, Inc. was a biotechnology company based in Cambridge, MA that developed therapies for type 2 diabetes, cancer, and other diseases. Conceived in 2004 by Harvard University biologist David Sinclair and Andrew Perlman, [1] and founded that year by Sinclair and Perlman, along with Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel, [2] the company was ...
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