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Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal women. [ 1 ] It was patented in 1986 and approved for medical use in 1996. [ 4 ]
In the 1920s, Kyusaku Ogino, a Japanese gynecologist, and Hermann Knaus, from Austria, working independently, each made the discovery that ovulation occurs about fourteen days before the next menstrual period. [13] Ogino used his discovery to develop a formula for use in aiding infertile women to time intercourse to achieve pregnancy.
Aromatase inhibitors are a common fertility treatment to treat women with PCOS. A meta-analysis analyzing live birth rates for women with PCOS treated with clomiphene compared to letrozole found that letrozole resulted in higher live birth rates. [11] However, ovulation induction remains an off-label indication, which affects use.
In case of amenorrhea, a period can be induced by intake of an oral progestin for 10 days. Daily administration of the ovulation induction regimen, starting on day 3, 4, or 5, [23] and it is usually taken for 5 days. [9] [24] Sexual intercourse or artificial insemination by the time of ovulation.
A CycleBeads birth control chain, used for a rough estimate of fertility based on days since menstruation. CycleBeads is a visual tool that was developed by the Institute for Reproductive Health at Georgetown University. This device helps women use the Standard Days Method, a fertility awareness-based family planning method. The sole ...
When used in conjunction with in vitro fertilization (IVF), controlled ovarian hyperstimulation confers a need to avoid spontaneous ovulation, since oocyte retrieval of the mature egg from the fallopian tube or uterus is much harder than from the ovarian follicle. The main regimens to achieve ovulation suppression are:
In healthy young men, levonorgestrel alone at a dose of 120 to 240 μg/day orally for 2 weeks suppressed testosterone levels from ~450 ng/dL to ~248 ng/dL (–45%). [59] Because of its effects on testosterone levels, and due to its androgenic activity being only weak and hence insufficient for purposes of androgen replacement in males ...
To allow the Y sperm, which supposedly moves faster, to reach the egg first, use deeper penetration to deposit the sperm at the least acidic area near the uterus opening. Intercourse should occur from 5 am and continue every 2 hours during the ovulation period. Eggs are more likely to be fertilized before 7 am known as "the peak period".