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Use of antidepressants during pregnancy may result in fetus abnormalities affecting functional development of the brain and behavior. [89] Studies have shown correlations between pregnant women treated with SNRIs and risk of hypertensive disorders, [90] preeclampsia, [91] miscarriage, [92] seizures in children, [93] and many other adverse affects.
[5] [8] It is unclear if use during pregnancy or breastfeeding is safe. [9] Desvenlafaxine was approved for medical use in the United States in 2008. [5] In Europe its application for use was denied in 2009. [6] In 2022, it was the 208th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [10] [11]
Enoxaparin is listed as Pregnancy Category B, meaning animal studies have failed to show harmful effects to the fetus and therefore are safe to use in pregnant women. [ 37 ] [ 39 ] However, pregnant women taking LMWH may not experience the full anticoagulant effect due to the nature of the medication compared to other anticoagulants (i.e ...
Tricyclic antidepressants are older antidepressants that, due to their side effect profiles, typically aren’t prescribed as first-line depression treatments today.
Nortriptyline may cause problems if taken during pregnancy. [8] Use during breastfeeding appears to be relatively safe. [7] It is a tricyclic antidepressant (TCA) and is believed to work by altering levels of serotonin and norepinephrine. [8] Nortriptyline was approved for medical use in the United States in 1964. [8]
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It is unclear if use during pregnancy is safe. [12] How it works is not clear, but it may involve blocking certain adrenergic and serotonin receptors. [11] [12] Chemically, it is a tetracyclic antidepressant, [12] and is closely related to mianserin. It also has strong antihistaminergic effects. [11] [12]
The number of people with depression has reached new highs—and so has antidepressant use. As Americans are increasingly reaching for pharmaceutical solutions for depression—about one in eight ...