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Lipoproteins released from treatment of Treponema pallidum infections are believed to induce the Jarisch–Herxheimer reaction. [3] The Herxheimer reaction has shown an increase in inflammatory cytokines during the period of exacerbation, including tumor necrosis factor alpha , interleukin-6 and interleukin-8 .
Adolf Jarisch (February 15, 1850 – March 21, 1902) was an dermatologist from the Austro-Hungarian Empire who specialized in the care of venereal disease.The Jarisch-Herxheimer reaction, an inflammatory response that he noted following treatment for syphilis, is partially named after him.
The Jarisch-Herxheimer reaction, which is the response to the body after endotoxins are released by the death of harmful organisms in the human body, starts usually during the first day of antibiotic treatment. [16] The reaction increases the person's body temperature, decreases the overall blood pressure (both systolic and diastolic levels ...
The Jarisch–Herxheimer reaction is an immune-mediated response to syphilis therapy occurring within 2–24 hours. The exact mechanisms of reaction are unclear, however most likely caused by proinflammatory treponemal lipoproteins that are released from dead and dying organisms following antibiotic treatment.
Mycoplasma pneumonia is caused by a bacterium that can spread through droplets when an infected person coughs or sneezes. The bacterium can linger in the nose and throat without making a person ...
All patients treated with antibiotics should be observed during the first 4 hours of treatment for a Jarisch-Herxheimer reaction, which is a worsening of symptoms characterized by rigors, hypotension, and high fever. [5] The reaction occurs in over 50% of cases and may be difficult to distinguish from a febrile crisis. [5]
Rates of Mycoplasma pneumonia in all global community-acquired pneumonia (CAP) cases range from 10-15%. [13] [14] The rate of Mycoplasma pneumonia in adults with CAP is estimated to be 15%, and the rate of in children with CAP has been reported at 27.4%. [3] The rates of M. pneumoniae among hospitalized CAP cases are 35% in adults [14] and 24% ...
Karl Herxheimer (German pronunciation: [kaʁl ˈhɛʁksˌhaɪmɐ]; 26 June 1861 – 6 December 1942) was a German-Jewish dermatologist who was a native of Wiesbaden. He studied medicine at the universities of Freiburg , Strasbourg and Würzburg , receiving his doctorate in 1885 with a thesis on cerebral syphilis.