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The binding of ligands to G-quadruplexes is vital for anti-cancer pursuits because G-quadruplexes are found typically at translocation hot spots. MM41, a ligand that binds selectively for a quadruplex on the BCL-2 promoter, is shaped with a central core and 4 side chains branching sterically out.
G-quadruplexes are also potential targets for cancer therapy. Triplexes are three-stranded DNA structures formed by the binding of a third strand to a DNA duplex. [ 5 ] Triplexes can be formed by pyrimidine-rich or purine-rich third strands, and they can occur in genomic regions with inverted repeats, mirror repeats, or other special sequences.
Due to i-motif formation in acidic conditions and cancer cells having acidic endosomes, cancer therapy and theranostic applications have been investigated. In a study by Takahashi et al., it was found that by using carboxyl-modified single-walled carbon nanotubes (C-SWNTs), telomerase activity could be inhibited, which could potentially lead to ...
In July 2023 Qualigen Therapeutics Inc received IND clearance from the FDA to initiate a Phase 1 clinical trial of QN-302 for the treatment of advanced or metastatic solid tumors. Neidle has published over 500 papers and reviews, [ 2 ] 14 patents, edited nine books and has written four books on nucleic acid structure, drug-DNA interactions and ...
Photoimmunotherapy (PIT) is an oncological treatment that combines photodynamic therapy of tumor with immunotherapy treatment. Combining photodynamic therapy with immunotherapy enhances the immunostimulating response and has synergistic effects for metastatic cancer treatment. [1] [2] [3]
All cancer treatment modalities (e.g., chemotherapy, targeted drugs, radiation and surgery) trigger systemic and local effects in the treated subject (i.e., the host). These include a rapid elevation in the levels of circulating cytokines , chemokines , growth factors and enzymes accompanied by acute mobilization and tumor homing of bone-marrow ...
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