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A study found that oral spironolactone had "about 10 to 20% of the feminizing effect of cyproterone acetate" on sexual differentiation in male rat fetuses, with a dose of 40 mg/day spironolactone having an effect equal to 1–3 mg/day cyproterone acetate. [35] [36]
Most of the side effects of spironolactone are dose-dependent. [62] Low-dose spironolactone is generally very well tolerated. [62] Even higher doses of spironolactone, such as 100 mg/day, are well tolerated in most individuals. [62]
Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. [5] [6] [7] The active metabolites of spironolactone have extended terminal half-lives of 13.8 hours for 7α-TMS, 15.0 hours for 6β-OH-7α-TMS, and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug. [5] [6
Spirolactones are a class of functional group in organic chemistry featuring a cyclic ester attached spiro to another ring system. The name is also used to refer to a class of synthetic steroids, called steroid-17α-spirolactones, 17α-spirolactosteroids, or simply 17α-spirolactones, which feature their spirolactone group at the C17α position.
Deprescribing is an option for patients who experience unpleasant side effects, said Sue Clenton, MD, a consultant clinical oncologist at Weston Park Cancer Centre in Sheffield, U.K.
Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. [5] [6] [7] The active metabolites of spironolactone have extended terminal half-lives of 13.8 hours for 7α-TMS, 15.0 hours for 6β-OH-7α-TMS, and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug. [5] [6]
Two men "brutally attacked and killed" a friend after wrongly accusing him of stealing a bank card. Jonathan Hutty, 49, was "violently assaulted" and found with a severe head injury inside a flat ...
Ariana Grande and Cynthia Erivo "received equal pay for their work on 'Wicked,'" a spokesperson for the studio said
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related to: therapeutic effects of spironolactone 20 gram dosage"The lowest prices on generic prescriptions." - The New York Times