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Hypertensive nephropathy refers to kidney failure that can be attributed to a history of hypertension [7] It is a chronic condition and it is a serious risk factor for the development of end-stage kidney disease (ESKD). However, despite the well-known association between hypertension and chronic kidney disease, the underlying mechanism remains ...
A diagram explaining factors affecting arterial pressure. Pathophysiology is a study which explains the function of the body as it relates to diseases and conditions. The pathophysiology of hypertension is an area which attempts to explain mechanistically the causes of hypertension, which is a chronic disease characterized by elevation of blood pressure.
Renovascular hypertension is a condition in which high blood pressure is caused by the kidneys' hormonal response to narrowing of the arteries supplying the kidneys. [1] When functioning properly this hormonal axis regulates blood pressure. Due to low local blood flow, the kidneys mistakenly increase blood pressure of the entire circulatory system.
It has many different causes including obstructive sleep apnea, kidney disease, endocrine diseases, and tumors. The cause of secondary hypertension varies significantly with age. [1] It also can be a side effect of many medications.
Once the diagnosis of hypertension has been made, further testing may be performed to find secondary hypertension, identify comorbidities such as diabetes, identify hypertension-caused organ damage such as chronic kidney disease or thickening of the heart muscle, and for cardiovascular disease risk stratification.
Benign nephrosclerosis alone hardly ever causes severe damage to the kidney, except in susceptible populations, such as African Americans, where it may lead to uremia and death. However, all persons with this disease usually show some functional impairment, such as loss of concentration or a variably diminished GFR.
Normal. Less than 120 and. Less than 80. Elevated. 120-129 and. Less than 80. Stage 1 Hypertension. 130-139 or. 80-89. Stage 2 Hypertension. 140 or higher or. 90 or higher
Causes of acute kidney failure include low blood pressure, blockage of the urinary tract, certain medications, muscle breakdown, and hemolytic uremic syndrome. [6] Causes of chronic kidney failure include diabetes, high blood pressure, nephrotic syndrome, and polycystic kidney disease. [6]
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