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The book criticizes estrogen replacement therapy and proposes the use of "natural progesterone" for menopausal women in order to alleviate a variety of complaints. Lee's theories have been criticized for being inadequately supported through science, being primarily based on anecdotal evidence with no rigorous research to support them. [ 4 ]
The term SERM was introduced to describe these compounds that have a combination of estrogen agonist, partial agonist, or antagonist activities depending on the tissue. [5] Toremifene has been shown to be compatible with tamoxifen, and in 1996 it was approved for use in the treatment of breast cancer in postmenopausal women. [38]
Perimenopausal Estrogen Replacement Therapy Study (PERT) [11] [12] [13] Postmenopausal Estrogen/Progestin Interventions (PEPI) Stockholm Trial or Stockholm Randomized Trial [14] [15] [10] Women's Estrogen for Stroke Trial (WEST) Women's Estrogen Lipid-Lowering Hormone Atherosclerosis Regression Trial (WELL-HART) Women's Health Initiative ...
According to board-certified celebrity dermatologist Dr. Kim Nichols, MD, FAAD, low estrogen levels can be the cause of these skin conditions leading to a variety of symptoms that affect both ...
The four major naturally occurring estrogens in women are estrone (E1), estradiol (E2), estriol (E3), and estetrol (E4). Estradiol (E2) is the predominant estrogen during reproductive years both in terms of absolute serum levels as well as in terms of estrogenic activity.
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