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Epithelial polarity is one example of the cell polarity that is a fundamental feature of many types of cells. Epithelial cells feature distinct 'apical', 'lateral' and 'basal' plasma membrane domains. Epithelial cells connect to one another via their lateral membranes to form epithelial sheets that line cavities and surfaces throughout the ...
Epithelial cells also exhibit planar cell polarity, in which specialized structures are orientated within the plane of the epithelial sheet. Some examples of planar cell polarity include the scales of fish being oriented in the same direction and similarly the feathers of birds, the fur of mammals, and the cuticular projections (sensory hairs ...
Epithelium or epithelial tissue is a thin, continuous, protective layer of cells with little extracellular matrix. An example is the epidermis , the outermost layer of the skin . Epithelial ( mesothelial ) tissues line the outer surfaces of many internal organs , the corresponding inner surfaces of body cavities , and the inner surfaces of ...
Planar cell polarity (PCP) is the protein-mediated signaling that coordinates the orientation of cells in a layer of epithelial tissue. In vertebrates, examples of mature PCP oriented tissue are the stereo-cilia bundles in the inner ear, [ 1 ] motile cilia of the epithelium, [ 2 ] and cell motility in epidermal wound healing. [ 3 ]
The epithelial–mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell–cell adhesion, and gain migratory and invasive properties to become mesenchymal stem cells; these are multipotent stromal cells that can differentiate into a variety of cell types.
Form the mechanical link between cells which can densely pack the epithelial sheaths. [5] Intermediate the adjacent cells interaction. [6] Prevent the free diffusion of water and solutes among adjacent epithelial cells. [2] [13] Preserve the epithelial polarity and cell adhesion. [2]
69697 Ensembl ENSG00000076826 ENSMUSG00000044433 UniProt Q9P1Y5 Q80VC9 RefSeq (mRNA) NM_001080429 NM_020902 NM_001163749 NM_027171 NM_001347111 NM_001347112 NM_001347113 RefSeq (protein) NP_001073898 NP_065953 NP_001157221 NP_001334040 NP_001334041 NP_001334042 NP_081447 NP_001350168 NP_001350169 NP_001350170 NP_001350171 NP_001350172 NP_001350173 NP_001350174 NP_001350175 NP_001350176 NP ...
Cell junctions are especially abundant in epithelial tissues. Combined with cell adhesion molecules and extracellular matrix, cell junctions help hold animal cells together. Cell junctions are also especially important in enabling communication between neighboring cells via specialized protein complexes called communicating (gap) junctions ...