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Testosterone is the primary male sex hormone and androgen in males. [3] In humans, testosterone plays a key role in the development of male reproductive tissues such as testicles and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.
Testosterone is the primary androgen — or male hormone — in your body. Low testosterone affects up to 39 percent of adult men in the US over the age of 45, and becomes increasingly prevalent ...
[19] [20] Aromatization of testosterone into the estrogen estradiol appears to be partially responsible for the effects of testosterone on sexual desire and function in men. [ 21 ] [ 22 ] [ 23 ] 5α-Reduction of testosterone into the more potent androgen dihydrotestosterone (DHT) may have a small contribution to the effects of testosterone on ...
Normal function of the androgen receptor. Testosterone (T) enters the cell and, if 5-alpha-reductase is present, is converted into dihydrotestosterone (DHT). Upon steroid binding, the androgen receptor (AR) undergoes a conformational change and releases heat-shock proteins (hsps). Phosphorylation (P) occurs before or after steroid binding.
Conversely, “with too much testosterone, women often have acne, too much hair on the body, hair loss on the head, high blood pressure, elevated cholesterol, skipped cycles, or problems ...
Testosterone levels very with age, according to the Cleveland Clinic, and start to drop around age 30 or 40. Women turn to weight loss drugs in menopause: What to know about the benefits and risks
Dihydrotestosterone (DHT) is a metabolite of testosterone, and a more potent androgen than testosterone in that it binds more strongly to androgen receptors. It is produced in the skin and reproductive tissue. A4 and testosterone can also have an extra hydroxyl (-OH) or keton (=O) group bound on position 11.
The elimination half-life of DHT in the body (53 minutes) is longer than that of testosterone (34 minutes), and this may account for some of the difference in their potency. [51] A study of transdermal (patches) DHT and testosterone treatment reported terminal half-lives of 2.83 hours and 1.29 hours, respectively.