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Hepatic arterial infusion (HAI) is a medical procedure that delivers chemotherapy directly to the liver.The procedure, mostly used in combination with systemic chemotherapy, plays a role in the treatment of liver metastases in patients with colorectal cancer (CRC). [1]
Barcelona Clinic Liver Cancer (BCLC) Staging System. The prognosis of HCC is affected by the staging of the tumor, the liver's function due to the effects of chronic liver disease and cirrhosis as well as the person's physical performance status. [48] A number of staging classifications for HCC are available.
For example, it is recommended that people with chronic liver disease who are at risk for hepatocellular carcinoma be screened every 6 months using ultrasound imaging. [ 8 ] Because liver cancer is an umbrella term for many types of cancer, the signs and symptoms depend on what type of cancer is present.
Even when surgical removal is successful chemotherapy and radiation therapy are generally recommended. [1] In certain cases surgery may include a liver transplantation. [3] Even when surgery is successful the 5-year survival is typically less than 50%. [6]
But the bigger concern is that the cancer will come back in the bones, liver or lungs, as metastatic disease is much harder to treat, Dr. Eric Winer, director of the Yale Cancer Center, explains.
The liver damage can consist of damage to liver cells, hepatic sinusoidal syndrome (obstruction of the veins in the liver), cholestasis (where bile does not flow from the liver to the intestine) and liver fibrosis. [127] [128] Nephrotoxicity (kidney damage) can be caused by tumor lysis syndrome and also due direct effects of drug clearance by ...
Hepatic veno-occlusive disease (VOD) or veno-occlusive disease with immunodeficiency is a potentially life-threatening condition in which some of the small veins in the liver are obstructed. It is a complication of high-dose chemotherapy given before a bone marrow transplant or excessive exposure to hepatotoxic pyrrolizidine alkaloids .
A liver support system or diachysis is a type of therapeutic device to assist in performing the functions of the liver. Such systems focus either on removing the accumulating toxins (liver dialysis), or providing additional replacement of the metabolic functions of the liver through the inclusion of hepatocytes to the device (bioartificial liver device).