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They may require more intensive chemotherapy. [16] Therefore, some studies have shown that the condition is harder to cure if the cancer has spread to the liver or brain or β-hCG level is higher than 40,000 mIU/mL when treatment begins, cancer returns after having chemotherapy or symptoms/ pregnancy occurred for more than 4 months before ...
It is also recommended that, while on the drug, one should avoid those having recently received oral polio vaccine. This drug was formerly not recommended during pregnancy and early evidence indicated pregnant women on the drug (or the related azathioprine ) showed a seven-fold incidence of fetal abnormalities as well as a 20-fold increase in ...
[17] [19] Deaths due to toxicity accounted for 1.7% of the 2045 patients, and incidence was increased (9.8%) in patients with elevated baseline liver function tests (liver dysfunction). [17] [19] The use of docetaxel during chemotherapy, especially when given weekly, may lead to complications with the lacrimal drainage system.
There are concerns from animal studies that it may increase the risk of cancer but these concerns have not been found in human trials. [5] Nifurtimox is not recommended in pregnancy or in those with significant kidney or liver problems. [5] It is a type of nitrofuran. [5] Nifurtimox came into medication use in 1965. [5]
The liver damage can consist of damage to liver cells, hepatic sinusoidal syndrome (obstruction of the veins in the liver), cholestasis (where bile does not flow from the liver to the intestine) and liver fibrosis. [127] [128] Nephrotoxicity (kidney damage) can be caused by tumor lysis syndrome and also due direct effects of drug clearance by ...
Other serious side effects include liver problems and allergic reactions. [3] It is unclear if use in pregnancy is safe for the baby. [3] Dacarbazine is in the alkylating agent and purine analog families of medication. [3] Dacarbazine was approved for medical use in the United States in 1975. [3]
Acute fatty liver of pregnancy is a rare life-threatening complication of pregnancy that occurs in the third trimester or the immediate period after delivery. [1] It is thought to be caused by a disordered metabolism of fatty acids by mitochondria in the fetus, caused by long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency. [2]
Trilostane should not be used in pregnant women. [1] Trilostane should not be given to a dog that: Has kidney or liver disease [12] [13] Takes certain medications used to treat cardiovascular disease [14] Is pregnant, nursing or intended for breeding [12] [13]