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The higher the blood:gas partition coefficient, the slower the rate of induction. Newer anesthetics (such as desflurane ) typically have smaller blood–gas partition coefficients than older ones (such as ether ); this leads to faster onset of anesthesia and faster emergence from anesthesia once application of the anesthetic is stopped, which ...
For example, the blood/gas partition coefficient of a general anesthetic measures how easily the anesthetic passes from gas to blood. [5] Partition coefficients can also be defined when one of the phases is solid, for instance, when one phase is a molten metal and the second is a solid metal, [6] or when both phases are solids. [7]
′ denotes the end-capillary partial pressure of the gas (mmHg) This equation is the foundation for the MIGET, and it demonstrates that the fraction of inert gas not eliminated from the blood via the lung is a function of the partition coefficient and the V A /Q ratio. This equation operates under the presumption that the lung is ...
The partition coefficient of a gaseous drug is indicative of its relative solubility in various tissues. This metric is the relative drug concentration between two tissues, when their partial pressures are equal (gas:blood, fat:blood, etc.).
E.g., multiplying the proposed population mean of approximately / acetone in end-tidal breath by the partition coefficient = at body temperature grossly underestimates observed (arterial) blood levels spreading around /. Furthermore, breath profiles of acetone (and other highly soluble volatile compounds such as 2-pentanone or methyl acetate ...
Packaging of Fluothane brand of halothane. It is a potent anesthetic with a minimum alveolar concentration (MAC) of 0.74%. [14] Its blood/gas partition coefficient of 2.4 makes it an agent with moderate induction and recovery time. [15]
Blood:gas partition coefficient: 1.4 Oil:gas partition coefficient: 98 It is administered as a racemic mixture of (R)- and (S)-optical isomers. [29]
Cyclopropane is a relatively potent, non-irritating and sweet smelling agent with a minimum alveolar concentration of 17.5% [9] and a blood/gas partition coefficient of 0.55. This meant induction of anaesthesia by inhalation of cyclopropane and oxygen was rapid and not unpleasant.