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The artificial repressilator is a milestone of synthetic biology which shows that genetic regulatory networks can be designed and implemented to perform novel functions. However, it was found that the cells' oscillations drifted out of phase after a period of time and the artificial repressilator's activity was influenced by cell growth.
The lac operon: 1: RNA Polymerase, 2: lac repressor, 3: Promoter, 4: Operator, 5: Lactose, 6: lacZ, 7: lacY, 8: lacA. Top: The gene is essentially turned off.There is no lactose to inhibit the repressor, so the repressor binds to the operator, which obstructs the RNA polymerase from binding to the promoter and making lactase.
The goal of synthetic biology is to generate an array of tunable and characterized parts, or modules, with which any desirable synthetic biological circuit can be easily designed and implemented. [2] These circuits can serve as a method to modify cellular functions, create cellular responses to environmental conditions, or influence cellular ...
In genetics and cell biology, repression is a mechanism often used to decrease or inhibit the expression of a gene. Removal of repression is called derepression. This mechanism may occur at different stages in the expression of a gene, all resulting with increasing the overall RNA or protein products.
Pseudo-response regulator (PRR) refers to a group of genes that regulate the circadian oscillator in plants. There are four primary PRR proteins (PRR9, PRR7, PRR5 and TOC1/PRR1) that perform the majority of interactions with other proteins within the circadian oscillator, and another (PRR3) that has limited function.
While not meeting the previous definition of (transcriptional) attenuation, these are now considered to be variants of the same phenomena [3] and are included in this article. Attenuation is an ancient regulatory system, prevalent in many bacterial species providing fast and sensitive regulation of gene operons and is commonly used to repress ...
For transcription to take place, the enzyme that synthesizes RNA, known as RNA polymerase, must attach to the DNA near a gene.Promoters contain specific DNA sequences such as response elements that provide a secure initial binding site for RNA polymerase and for proteins called transcription factors that recruit RNA polymerase.
Oscillations are an important type of cell signaling characterized by the periodic change of the system in time. [1] Oscillations can take place in a biological system in a multitude of ways.