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Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells. Though temsirolimus shows activity on its own, it is also known to be converted to sirolimus (rapamycin) in vivo; [4] therefore, its activity may be more attributed to its metabolite rather than the prodrug itself (despite claims to the ...
2475 56717 Ensembl ENSG00000198793 ENSMUSG00000028991 UniProt P42345 Q9JLN9 RefSeq (mRNA) NM_004958 NM_001386500 NM_001386501 NM_020009 RefSeq (protein) NP_004949 NP_064393 Location (UCSC) Chr 1: 11.11 – 11.26 Mb Chr 4: 148.53 – 148.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The mammalian target of rapamycin (mTOR), also referred to as the mechanistic target of rapamycin ...
Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa).
Besides mammals, serotonin is found in all bilateral animals including worms and insects, [19] as well as in fungi and in plants. [20] Serotonin's presence in insect venoms and plant spines serves to cause pain, which is a side-effect of serotonin injection. [21] [22] Serotonin is produced by pathogenic amoebae, causing diarrhea in the human ...
1576 n/a Ensembl ENSG00000160868 n/a UniProt P08684 n/a RefSeq (mRNA) NM_001202855 NM_001202856 NM_001202857 NM_017460 n/a RefSeq (protein) NP_001189784 NP_059488 n/a Location (UCSC) Chr 7: 99.76 – 99.78 Mb n/a PubMed search n/a Wikidata View/Edit Human Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine ...
The authors of the January preprint named these sequences "obelisks" due to a predicted rod-like secondary structure: "At 1164 nt [nucleotides] in length, the rod-like secondary structure was striking [...]" [3] Viroids were known to exist in plants and cause pathology, and there had been no evidence that they were in animals or bacteria. [5]
22166 Ensembl ENSG00000136810 ENSMUSG00000028367 UniProt P10599 P10639 RefSeq (mRNA) NM_003329 NM_001244938 NM_011660 RefSeq (protein) NP_001231867 NP_003320 NP_035790 Location (UCSC) Chr 9: 110.24 – 110.26 Mb Chr 4: 57.94 – 57.96 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thioredoxin (TRX or TXN) is a class of small redox proteins known to be present in all organisms. It ...
The female counterpart to the antheridium in cryptogams is the archegonium, and in flowering plants is the gynoecium. An antheridium typically consists of sterile cells and spermatogenous tissue. The sterile cells may form a central support structure or surround the spermatogenous tissue as a protective jacket.