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Although the FDA has approved ketamine for use as an injected or intravenous anesthetic, ketamine infusion therapy hasn’t been approved to treat chronic pain, depression, or other conditions.
Ketamine IV infusions are safe and effective, but there are risks to be aware of. ... Ketamine was FDA-approved in 1970 as an anesthetic and has many more studies and 50-plus years of safety and ...
In October 2023, the FDA warned about using the substance to treat psychiatric disorders in non-injectable forms, noting that safety concerns that may be associated with ketamine usage include ...
Ketamine-assisted psychotherapy (KAP) is the use of prescribed doses of ketamine as an adjunct to psychotherapy sessions. KAP shows significant potential in treating mental disorders such as treatment-resistant depression (TRD), anxiety , obsessive–compulsive disorders (OCD), post-traumatic stress disorders (PTSD), and other conditions. [ 1 ]
The only form of ketamine that is FDA-approved for treatment-resistant depression is Spravato, which includes one molecule of ketamine and only comes in the form of a nasal spray.
Following FDA approval in 1970, ketamine anesthesia was first given to American soldiers during the Vietnam War. [142] The discovery of antidepressive action of ketamine in 2000 [143] has been described as the single most important advance in the treatment of depression in more than 50 years.
After the publication of the NIH-run antidepressant clinical trial, clinics began opening in which the intravenous ketamine is given for depression. [5] [6] This practice is an off label use of IV ketamine in the United States, though the intranasal version of esketamine has been approved by the FDA for treatment of depression [5] [7] In 2015 there were about 60 such clinics in the US; the ...
The FDA says it has not approved the use of the drug for treating psychiatric disorders, but there have still been documented uses of compounded ketamine to treat disorders including depression ...