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Sibutramine, formerly sold under the brand name Meridia among others, is an appetite suppressant which has been discontinued in many countries. It works as a serotonin–norepinephrine reuptake inhibitor (SNRI) similar to certain antidepressants .
Sibutramine (Reductil/Meridia) 2010 Australia, [49] Canada, [50] China, [51] the European Union (EU), [52] Hong Kong, [53] India, [54] Mexico, New Zealand, [55] the Philippines, [56] Thailand, [57] the United Kingdom, [58] and the United States [59] Increased risk of heart attack and stroke. [2] Sitaxentan: 2010 Germany Hepatotoxicity. [14 ...
Orlistat (Xenical), the most commonly used medication to treat obesity and sibutramine (Meridia), a medication that was withdrawn due to cardiovascular side effects. Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control excess body fat.
Sibutramine is the name of an SNRI based appetite suppressant with use in the treatment of obesity. This was explored in the treatment of depression, but was shown not to be effective. Both sibutramine and venlafaxine are phenethylamine-based. At high doses, both venlafaxine and sibutramine will start producing dopaminergic effects.
OPC-64005 is a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), or "triple reuptake inhibitor" (TRI), which is under development for the treatment of major depressive disorder.
NS-2359 (GSK-372475) is a serotonin-norepinephrine-dopamine reuptake inhibitor.It was under development by GlaxoSmithKline (GSK) as an antidepressant, [1] but was discontinued in 2009 when phase II clinical trials showed the drug was not effective and not well tolerated. [2]
A category for drugs withdrawn from the market after marketing commenced for any reason (voluntarily or involuntarily). For drug candidates that were abandoned prior to being marketed due to side effects, lack of efficacy, superior competitors, or other reasons, see Category:Abandoned drugs
Fenethylline (Biocapton, Captagon, Fitton) – amphetamine and theophylline prodrug — discontinued/no longer used Levoamphetamine (Cydril) – discontinued/no longer used [ 116 ] Lisdexamfetamine (Elvanse, Tyvense, Venvanse, Vyvanse) – dextroamphetamine prodrug [ 117 ]