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Chlorthalidone and hydrochlorothiazide are diuretics used to lower blood pressure. Learn more about the primary differences between these two medications.
Chlortalidone is considered a first-line medication for treatment of high blood pressure. [2] Some recommend chlortalidone over hydrochlorothiazide. [1] [15] A meta-analysis of randomized controlled trials found that chlortalidone is more effective than hydrochlorothiazide for lowering blood pressure, while the two drugs have similar toxicity.
Hydrochlorothiazide appears be more effective than chlorthalidone in preventing heart attacks and strokes. [14] Hydrochlorothiazide is less potent but may be more effective than chlorthalidone in reducing blood pressure. [14] [15] More robust studies are required to confirm which drug is superior in reducing cardiovascular events. [16]
Thiazide diuretics are effective, recommended as the best first-line drug for hypertension, [52] and are much more affordable than other therapies, yet they are not prescribed as often as some newer drugs. Chlorthalidone is the thiazide drug that is most strongly supported by the evidence as providing a mortality benefit; in the ALLHAT study, a ...
The thiazide-like diuretics (indapamide and chlorthalidone) reduce risk of major cardiovascular events and heart failure in hypertensive patients compared with hydrochlorothiazide with a comparable incidence of adverse events. [5] Both thiazide diuretics and thiazide-like diuretics are effective in reducing risk of stroke.
A case study of two brothers with the condition, two years of treatment with hydrochlorothiazide reduced the incidence of kidney stones and improved kidney function. [22] The thiazide-like diuretic chlortalidone reduced urine calcium oxalate in seven of the eight males with inactivated CLCN5 gene that participated in the study. [23]
According to the Novartis web site, Chlorthalidone is a Thiazide-based diuretic (that is NOT marketed in the UK according to Novartis #1) and Chlortalidone appears to be a Sulfonamide-based diuretic marketed by Sandoz. Perhaps the spelling was changed in the UK because of the product difference between Novartis and Sandoz.
Rather than track points (the traditional WW program uses a point system to help you track food and encourage healthy choices), the GLP-1 plan had me strive for certain target amounts of protein ...