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Common side effects include nausea ... Possibly by promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused ...
Fosphenytoin, also known as fosphenytoin sodium, and sold under the brand name Cerebyx among others, is a water-soluble phenytoin prodrug that is administered intravenously to deliver phenytoin, potentially more safely than intravenous phenytoin. It is used in the acute treatment of convulsive status epilepticus. Fosphenytoin was developed in 1996.
Fetal hydantoin syndrome, also called fetal dilantin syndrome, is a group of defects caused to the developing fetus by exposure to teratogenic effects of phenytoin. Dilantin is the brand name of the drug phenytoin sodium in the United States, commonly used in the treatment of epilepsy .
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Purple glove syndrome is caused by the intravenous anticonvulsant phenytoin. [3] This medication has many already established neurological side effects. However, glove syndrome is a rare, with prevalence ranging from 1.7% to 5.9%, but has very serious adverse effect that may lead to limb amputations.
Documented side effects include: Short-term water retention. Gastric distress. Muscle cramping. Dehydration. Some side effects may be more likely with larger doses and hot environments.
Elon Musk looks on, in the Oval Office of the White House in Washington, D.C., U.S. - Kevin Lamarque/Reuters
The hydantoin group can be found in several medicinally important compounds. [1] In pharmaceuticals, hydantoin derivatives form a class of anticonvulsants; [8] phenytoin and fosphenytoin both contain hydantoin moieties and are both used as anticonvulsants in the treatment of seizure disorders.