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Amlodipine causes several drugs to increase in levels, including cyclosporine, simvastatin, and tacrolimus (the increase in the last one being more likely in people with CYP3A5*3 genetic polymorphisms). [39] When more than 20 mg of simvastatin, a lipid-lowering agent, are given with amlodipine, the risk of myopathy increases. [40]
A general lack of energy, fatigue, and tiredness that cannot be otherwise explained is also a symptom of a major depressive episode. [3] A person may feel tired without engaging in any physical activity, which may cause day-to-day tasks, such as showering, to become unmanageable. [10]
There exists no overdose data on amiloride in humans, though it is expected than an overdose would produce effects consistent with its therapeutic effects; e.g. dehydration due to over-diuresis, and electrolyte disturbances related to hyperkalemia. It is unknown if amiloride can be dialyzed off, and no specific antidote against it exists.
Amlodipine/olmesartan, sold under the brand name Azor, among others is a fixed-dose combination medication used to treat high blood pressure. [5] It contains amlodipine , as the besilate, a dihydropyridine calcium channel blocker , and olmesartan medoxomil , an angiotensin II receptor blocker .
It is a reasonable initial treatment for high blood pressure. [2] It is taken by mouth. [2] Versions are available as the combinations benazepril/hydrochlorothiazide and benazepril/amlodipine. [2] Common side effects include feeling tired, dizziness, cough, and light-headedness with standing. [2]
Some CCBs can also cause a fast heart rate as a result of the low blood pressure. [4] Other symptoms may include nausea, vomiting, sleepiness, and shortness of breath . [ 2 ] Symptoms usually occur in the first six hours but with some forms of the medication may not start until 24 after hours.
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Lethargy is a state of tiredness, sleepiness, weariness, fatigue, sluggishness, or lack of energy. It can be accompanied by depression , decreased motivation, or apathy . Lethargy can be a normal response to inadequate sleep, overexertion, overworking, stress, lack of exercise, improper nutrition, drug abuse, boredom , or a symptom of an ...
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