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Ketamine potentiates the sedative effects of propofol [85] and midazolam. [86] Naltrexone potentiates psychotomimetic effects of a low dose of ketamine, [87] while lamotrigine [38] and nimodipine [39] decrease them. Clonidine reduces the increase of salivation, heart rate, and blood pressure during ketamine anesthesia and decreases the ...
The use of ketamine as part of a "post-clubbing experience" has also been documented. [36] Ketamine's rise in the dance culture was most rapid in Hong Kong by the end of the 1990s. [32] Ketamine use as a recreational drug has been implicated in deaths globally, with more than 90 deaths in England and Wales in the years of 2005–2013. [37]
(CNN) — Matthew Perry’s 2023 death from what the Los Angeles County medical examiner’s office determined were “the acute effects of ketamine” cast a shadow over a medication that has ...
NMDA receptor antagonists induce a state called dissociative anesthesia, marked by catalepsy, amnesia, and analgesia. [1] Ketamine is a favored anesthetic for emergency patients with unknown medical history and in the treatment of burn victims because it depresses breathing and circulation less than other anesthetics.
Ketamine comes with a “unique set of risks, both to the individual but also to society,” including the potential for drug abuse and unknown effects of frequent use, especially at higher levels.
A 2000 landmark study showcased the drug's antidepressant and anti-suicidal effects, and more recent studies have supported ketamine's high rate of success in treating persistent depression.
When Gulur and her colleagues tracked 300 patients receiving ketamine at Duke, more than a third of them reported significant side effects that required professional attention, such as ...
Ketamine-assisted psychotherapy (KAP) is the use of prescribed doses of ketamine as an adjunct to psychotherapy sessions. KAP shows significant potential in treating mental disorders such as treatment-resistant depression (TRD), anxiety, obsessive–compulsive disorders (OCD), post-traumatic stress disorders (PTSD), and other conditions. [1]