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In United States pharmaceutical regulatory practice, a Complete Response Letter (CRL), or more rarely, a 314.110 letter, is a regulatory action by the Food and Drug Administration in response to a New Drug Application, Amended New Drug Application or Biologics License Application, indicating that the application will not be approved in its present form. [1]
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This reversible status can be used to note the temporary invalidity of the certificate (e.g., if the user is unsure if the private key has been lost). If, in this example, the private key was found and nobody had access to it, the status could be reinstated, and the certificate is valid again, thus removing the certificate from future CRLs.
The OCSP responder uses the certificate serial number to look up the revocation status of Alice's certificate. The OCSP responder looks in a CA database that Carol maintains. In this scenario, Carol's CA database is the only trusted location where a compromise to Alice's certificate would be recorded.
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OCSP suffers from scalability issues. It relies on the client having network access at the time of checking the certificate's revocation status; further, the OCSP responder must be accessible and produce usable responses, or else the check will fail and the client must choose between failing-soft and failing-hard.