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Advanced cardiac life support, advanced cardiovascular life support (ACLS) refers to a set of clinical guidelines established by the American Heart Association (AHA) for the urgent and emergent treatment of life-threatening cardiovascular conditions that will cause or have caused cardiac arrest, using advanced medical procedures, medications, and techniques.
Simulation can be carried out at different effective plasmatic therapeutic level of the drugs to identify the level at which cardiotoxicity cannot be neglected. The data collected could be finally managed to create a score system aimed to define the torsadogenic risk, namely the risk of inducing torsade de pointes, of the new drugs. [32] [33]
The core algorithm of ALS that is invoked when cardiac arrest has been confirmed, Advanced Cardiac Life Support (ACLS), relies on the monitoring of the electrical activity of the heart on a cardiac monitor. Depending on the type of cardiac arrhythmia, defibrillation and/or medication may be administered.
Once cardiac arrest is identified, cardiopulmonary resuscitation is commenced as per local resuscitation algorithms. With the assistance of emergency medical services and in hospital resuscitation teams, all patients with out-of hospital and in hospital arrests are assessed for their eligibility for ECPR.
For management of pediatric cardiac arrest, CPR should be initiated if suspected. Guidelines provide algorithms for pediatric cardiac arrest management. Recommended medications during pediatric resuscitation include epinephrine, lidocaine, and amiodarone. [163] [81] [82] However, the use of sodium bicarbonate or calcium is not recommended.
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