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Mechanism of self-amplifying mRNA (saRNA) used for antigen production. The ORF encoding the antigen can also be substituted with a protein for use in protein replacement therapy. This sequence encodes the protein of interest, used as an antigen in the case of vaccines or for protein replacement therapies. The gene of interest replaces the viral ...
Therapeutic use of saRNAs have been suggested. They have been tested in animal models to treat bladder tumors, [8] liver carcinogenesis, [9] [10] pancreatic cancer, [11] and erectile dysfunction. [12] In 2016, a phase I clinical trial involving advanced liver cancer patients [13] was launched for the saRNA drug MTL-CEBPA. It aimed to complete ...
Baked beans is a dish traditionally containing white common beans that are parboiled and then baked in sauce at low temperature for a lengthy period. [1] Canned baked beans are not baked, but are cooked through a steam process. [2] Baked beans originated in Native American cuisine, and are made from beans indigenous to the Americas. [3]
Drob sarma is a dish of finely chopped offal (liver and lung), rice, browned onions, herbs, baked in an oven, and after a while covered with a mixture of eggs and yogurt and baked again. [15] The dish may be covered or even wrapped in caul fat before being baked. All sarma dishes can be served with fresh yogurt on the side.
These are known variously as loaded potato skins, filled potatoes and twice-baked potatoes. In Great Britain, toppings or fillings include baked beans, curried chicken, coronation chicken, chili con carne, shredded cheese, tuna mayonnaise, and coleslaw. In Scotland even haggis is used as a filling for jacket potatoes.
Place on a baking sheet or on a heatproof rack inserted inside a baking sheet. Bake potatoes until easily pierced with a fork and an instant-read thermometer inserted into the center registers 200 ...
It's worth noting that you should always try to use fresh beans (i.e. ones that haven't been in the back of the pantry for years), as older beans, even if soaked, can often never become truly tender.
President-elect Donald Trump complained on Friday that American flags would still be lowered to half-staff in honor of the late President Jimmy Carter during Trump's Jan. 20 inauguration.