enow.com Web Search

Search results

  1. Results from the WOW.Com Content Network
  2. Retracted article on dopaminergic neurotoxicity of MDMA

    en.wikipedia.org/wiki/Retracted_article_on...

    "Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA [nb 1] ("ecstasy")", [1] is an article by George A. Ricaurte that was published in September 2002 in the peer-reviewed journal Science, one of the world's top academic journals.

  3. Methamphetamine - Wikipedia

    en.wikipedia.org/wiki/Methamphetamine

    [29] [30] Methamphetamine neurotoxicity causes adverse changes in brain structure and function, such as reductions in grey matter volume in several brain regions, as well as adverse changes in markers of metabolic integrity. [30] Methamphetamine belongs to the substituted phenethylamine and substituted amphetamine chemical classes.

  4. 3,4-Dihydroxymethamphetamine - Wikipedia

    en.wikipedia.org/wiki/3,4-Dihydroxymethamphetamine

    Along with 3,4-dihydroxyamphetamine (HHA; α-methyldopamine), HHMA may be involved in the serotonergic neurotoxicity of MDMA. [1] [5] [6] [3] However, findings in this regard are conflicting, and the neurotoxicity of MDMA and related agents may instead be based on their mechanism of action without involvement of metabolites. [3] [5] [6] [7] [8]

  5. As overdose rates rise, FDA calls for new medications to help ...

    www.aol.com/news/why-no-treatments-cocaine-meth...

    In 2021, about 1.6 million people ages 12 and up in the U.S. had a methamphetamine use disorder and 1.4 million had a cocaine use disorder, according to data from the Substance Abuse and Mental ...

  6. MDMA - Wikipedia

    en.wikipedia.org/wiki/MDMA

    3,4-Methyl enedioxy methamphetamine (MDMA), ... Elevations in brain temperature from MDMA use are positively correlated with MDMA-induced neurotoxicity. [15] ...

  7. α-Methyldopamine - Wikipedia

    en.wikipedia.org/wiki/Α-Methyldopamine

    However, the derivative metabolite 2,5-bis-(glutathion-S-yl)-α-methyldopamine (injected at ~1.5 times the usual per-kg MDMA dose) did in fact induce neurotoxicity, providing initial evidence that this metabolite may be the source of neuronal toxicity following the administration of MDA and MDMA, and the subsequent reduction in serotonergic axons.

  8. Amphetamine type stimulant - Wikipedia

    en.wikipedia.org/wiki/Amphetamine_type_stimulant

    Methamphetamine fatality from ATS have been reported after ingestion of a minimal dose of 1.3 mg/kg, while the estimated minimum lethal dose in a non-addicted adult is 200 mg. [14] [26] Generally, children are more likely to develop toxicity and have lower chances of developing tolerance.

  9. Neurotoxicity - Wikipedia

    en.wikipedia.org/wiki/Neurotoxicity

    Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. [1] It occurs when exposure to a substance – specifically, a neurotoxin or neurotoxicant – alters the normal activity of the nervous system in such a ...