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A 2005 study in Egypt showed tianeptine to be effective in men with depression and erectile dysfunction. [ 25 ] Tianeptine has been found to be effective in depression, in people with Parkinson's disease , [ 26 ] and with post-traumatic stress disorder [ 27 ] for which it was as safe and effective as fluoxetine and moclobemide .
Unlike other SSRIs used to treat depression, which have been associated with high incidences of sexual dysfunction, [19] dapoxetine is associated with low rates of sexual dysfunction. Taken as needed, dapoxetine has very mild adverse effects of decreased libido (<1%) and erectile dysfunction (<4%). [7]
Sexual dysfunction, such as decreased libido, abnormal orgasm, delayed ejaculation, and erectile dysfunction, are well-known side effects of SSRIs and serotonin–norepinephrine reuptake inhibitors (SNRIs). [18] In clinical trials, sexual dysfunction occurred more often with vortioxetine than with placebo and appeared to be dose-dependent.
For most men who use ED medications, these side effects aren’t serious. As a newer, more selective medication for ED, avanafil (Stendra) is less likely to produce certain side effects than other ...
Phentolamine, a non-selective alpha blocker, has also been tested to treat erectile dysfunction. By reducing vasoconstriction in the penis, there appears to be increased blood flow that aids in penile erection. Side effects associated with phentolamine include headache, flushing, and nasal congestion. [23]
Men who reported severe erectile dysfunction—difficulty getting and keeping an erection—improved 4.9 points on a scale of 6-30, with higher scores indicating better function.
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