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Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene. [4] [5] [6] [7]FRS2 is an 80 kDa membrane-anchored signal transducing adaptor protein (STAP) that links specific activated Receptor Tyrosine Kinases (RTKs) to multiple downstream signaling pathways, most notably the MAPK/ERK, PI3K/AKT/mTOR and PLCγ pathways. [8]
53892 Ensembl ENSG00000170836 ENSMUSG00000020525 UniProt O15297 Q9QZ67 RefSeq (mRNA) NM_003620 NM_016910 RefSeq (protein) NP_003611 NP_058606 Location (UCSC) Chr 17: 60.6 – 60.67 Mb Chr 11: 85.2 – 85.24 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene. The protein encoded by this gene is a member of ...
A protein is predicted to be "druggable" if it is a member of a protein family [4] for which other members of the family are known to be targeted by drugs (i.e., "guilt" by association). While this is a useful approximation of druggability, this definition has limitations for two main reasons: (1) it highlights only historically successful ...
Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. [6] Mutations of this gene are a step in the development of many cancers , specifically glioblastoma, lung cancer, breast cancer, and prostate cancer.
PHLPP is a member of the PPM family of phosphatases, which requires magnesium or manganese for their activity and are insensitive to most common phosphatase inhibitors, including [okadaic acid]. PHLPP1 and PHLPP2 have a similar domain structure, which includes a putative Ras association domain, a pleckstrin homology domain , a series of leucine ...
Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene. [5] [6] The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.
Phosphatase and tensin homolog (PTEN) antagonises PI3K by converting PI(3,4,5)P 3 into PI(4,5)P 2. Loss of PTEN function leads to over-activation of Akt and is common in cancer cells (PTEN is a tumour suppressor). SH2-containing Inositol Phosphatase (SHIP) also dephosphorylates PI(3,4,5)P 3, at the 5' position of the inositol ring. [22]
Low molecular weight phosphotyrosine protein phosphatase is an ... increased expression of ACP1 is a biomarker for poor prognosis in prostate cancer has been ...