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Cerebrolysin (developmental code name FPF-1070) is an experimental mixture of enzymatically-treated peptides derived from pig brain whose constituents can include brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and ciliary neurotrophic factor (CNTF).
Brain-derived neurotrophic factor (BDNF), or abrineurin, [5] is a protein [6] that, in humans, is encoded by the BDNF gene. [ 7 ] [ 8 ] BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a family which also includes NT-3 and NT-4 /NT-5.
Gestational vitamin D deficiency in rats is associated with reduced levels of neurotrophic factors NGF and GDNF. [7] NGF is the nerve growth factor, which is involved in neurotransmission. GDNF is the glial cell lined derived neurotrophic factor, which is involved in the survival and differentiation of dopaminergic neurons.
In cell culture, cycloprolylglycine increases brain derived neurotrophic factor (BDNF). [8] Some studies suggest that the pharmacological properties of Noopept are derived from its action as an activator of Hypoxia-inducible factor (HIF-1). [9] [10]
Moreover, uncontrolled neuropathic pain is a significant risk factor for suicide. [22] Certain classes of neuropathic pain may cause serious adverse effects necessitating hospital admission, for instance trigeminal neuralgia can present as a severe crisis where the patient may have difficulty talking, eating and drinking. [ 23 ]
Brain-derived neurotrophic factor (BDNF) is structurally similar to NGF, NT-3, and NT-4/5, [7] and shares the TrkB receptor with NT-4. [8] The brain-derived neurotrophic factor/TrkB system promotes thymocyte survival, as studied in the thymus of mice. [8]
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