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Sodium citrate/sodium lauryl sulfoacetate/glycerol sold under the brandname Microlax and Micolette Micro enema, among others, is a small tube of liquid gel that is used to treat constipation. [ 1 ] The main active ingredients are sodium lauryl sulfoacetate (0.90% w/v ), sodium citrate (9.0% w/v ) and glycerol .
The package leaflet supplied with the product is aimed at end-users. [3] A cartoon by Roy Doty depicting the package insert as overly long and complicated. In the United States, the Food and Drug Administration (FDA) determines the requirements for patient package inserts.
This often includes patients near the end of life (an estimated 1.65 million people are in hospice care in the US each year). [4] Because using the rectal route enables a rapid, safe, and lower cost alternative to administration of medications, [ 5 ] it may also facilitate the care of patients in long-term care or palliative care , or as an ...
Examples: glycerin suppositories (Hallens), sorbitol, lactulose, and polyethylene glycol (PEG - Colyte, MiraLax) [12] Lactulose works by the osmotic effect, which retains water in the colon; lowering the pH through bacterial fermentation to lactic, formic, and acetic acids; and increasing colonic peristalsis.
A suppository is a dosage form used to deliver medications by insertion into a body orifice (any opening in the body), where it dissolves or melts to exert local or systemic effects. There are three types of suppositories, each to insert into a different sections: rectal suppositories into the rectum , vaginal suppositories into the vagina ...
A rudimentary form of "dry" enema is the use of a non-medicated glycerin suppository. [1] However, due to the relative hardness of the suppository – necessary for its insertion into the human body – before glycerin can act, it must be melted by the heat of the body, and hence it does not take effect for up to an hour.
Macrogol 4000, pharmaceutical quality. Macrogol 3350, often in combination with electrolytes, is used for short-term relief of constipation as well as for long-term use in constipation of various causes, including in multiple sclerosis and Parkinson's disease patients (an often-overlooked non-motor symptom) as well as constipation caused by pharmaceutical drugs such as opioids and ...
One is a topical ointment, the other a rectal suppository. In the United Kingdom both products are contract manufactured by Patheon Limited on behalf of the Sanofi-Aventis group. [1] [2] Manufacture and distribution is provided by Sanofi Aventis subsidiaries [3] Hoechst and Hoechst Marion Roussel in other territories worldwide. [4]
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