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  2. Primidone - Wikipedia

    en.wikipedia.org/wiki/Primidone

    Primidone and the other enzyme-inducing anticonvulsants can cut the half-life of antipyrine roughly in half (6.2 ± 1.9 h vs. 11.2 ± 4.2 h), and increases the clearance rate by almost 70%. Phenobarbital reduces the half-life to 4.8 ± 1.3 and increases the clearance by almost 109%. [ 66 ]

  3. Antidepressant discontinuation syndrome - Wikipedia

    en.wikipedia.org/wiki/Antidepressant...

    Methods of prevention include gradually decreasing the dose among those who wish to stop, though it is possible for symptoms to occur with tapering. [2] [6] [4] Treatment may include restarting the medication and slowly decreasing the dose. [2] People may also be switched to the long-acting antidepressant fluoxetine which can then be gradually ...

  4. Drug withdrawal - Wikipedia

    en.wikipedia.org/wiki/Drug_withdrawal

    As noted above, many drugs should not be stopped abruptly [10] without the advice and supervision of a physician, especially if the medication induces dependence or if the condition they are being used to treat is potentially dangerous and likely to return once medication is stopped, such as diabetes, asthma, heart conditions and many ...

  5. 6 Signs Wellbutrin is Right for Your Depression Symptoms - AOL

    www.aol.com/6-signs-wellbutrin-depression...

    When stopped abruptly, Wellbutrin can cause withdrawal symptoms. If you develop side effects, it’s important not to make changes to your dosage or stop using Wellbutrin without first talking to ...

  6. The Real Reason Why Hoda Kotb Is Leaving the Today Show - AOL

    www.aol.com/lifestyle/real-reason-why-hoda-kotb...

    Today's Macy's Thanksgiving Day Parade may be Hoda Kotb's last time hosting. In September, she announced she would be stepping down from the Today show in January 2025.. After celebrating her 60th ...

  7. Acute intermittent porphyria - Wikipedia

    en.wikipedia.org/wiki/Acute_intermittent_porphyria

    Hot water baths or showers may lessen nausea temporarily, but can present a risk of burns or falls. [27] Seizures often accompany this disease. Most seizure medications exacerbate this condition due to their induction of cytochrome P450. Treatment can be problematic: Barbiturates and primidone must be avoided as they commonly precipitate ...

  8. There's a 'Wave of Death' in Every Human Brain. Scientists ...

    www.aol.com/theres-wave-death-every-human...

    When neural activity stops, it doesn’t stop abruptly, but over time. The team hopes to find ways to keep the brain functioning even when the heart and lungs fail. The brain doesn’t shut off ...

  9. Medication overuse headache - Wikipedia

    en.wikipedia.org/wiki/Medication_overuse_headache

    Abruptly discontinuing butalbital, for example, can actually induce seizures in some patients, although simple over the counter analgesics can safely be stopped by the patient without medical supervision. A long-acting analgesic/anti-inflammatory, such as naproxen (500 mg twice a day), can be used to ease headache during the withdrawal period.