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In this diagram of a duplicated chromosome, (2) identifies the centromere—the region that joins the two sister chromatids, or each half of the chromosome. In prophase of mitosis, specialized regions on centromeres called kinetochores attach chromosomes to spindle fibers. The centromere links a pair of sister chromatids together during cell ...
an inner kinetochore, which is tightly associated with the centromere DNA and assembled in a specialized form of chromatin that persists throughout the cell cycle; an outer kinetochore, which interacts with microtubules ; the outer kinetochore is a very dynamic structure with many identical components, which are assembled and functional only ...
In prophase of mitosis, specialized regions on centromeres called kinetochores attach chromosomes to spindle fibers. The monocentric chromosome is a chromosome that has only one centromere in a chromosome and forms a narrow constriction. Monocentric centromeres are the most common structure on highly repetitive DNA in plants and animals. [1]
The sister chromatids will be distributed to each daughter cell at the end of the cell division. Whereas if the chromosome is isobrachial (centromere at centre and arms of equal length), the p and q system is meaningless. At either end of a chromosome is a telomere, a cap of DNA that protects the rest of the chromosome from damage.
centromere A specialized DNA sequence within a chromosome that links a pair of sister chromatids. The primary function of the centromere is to act as the site of assembly for kinetochores, protein complexes which direct the attachment of spindle fibers to the centromere and facilitate segregation of the chromatids during mitosis or meiosis.
Centromeres are composed of a 177 base pair tandem repeat named the α-satellite repeat. [16] Pericentromeric heterochromatin, the DNA which surrounds the centromere and is important for structural maintenance, is composed of a mixture of different satellite subfamilies including the α-, β- and γ-satellites as well as HSATII, HSATIII, and ...
Centromeres are the sites where spindle fibers attach to newly replicated chromosomes in order to segregate them into daughter cells when the cell divides. Each eukaryotic chromosome has a single functional centromere that is seen as a constricted region in a condensed metaphase chromosome.
A karyogram or idiogram is a graphical depiction of a karyotype, wherein chromosomes are generally organized in pairs, ordered by size and position of centromere for chromosomes of the same size. Karyotyping generally combines light microscopy and photography in the metaphase of the cell cycle , and results in a photomicrographic (or simply ...