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In recognition of his contribution, the depth of invasion of melanoma is referred to by the eponym Breslow's depth. Subsequent studies confirmed and refined the role of depth of invasion in the prognosis of malignant melanoma. [2] [3] Currently, Breslow's depth is included in the AJCC staging guidelines for melanoma as a major prognostic factor.
A diagram showing the most common sites for melanoma to spread 5-year relative survival by stage at diagnosis for melanoma of the skin in the United States as of 2014. Factors that affect prognosis include: tumor thickness in millimeters (Breslow's depth), depth related to skin structures (Clark level), type of melanoma, presence of ulceration,
One notable biomarker garnering significant attention is the protein biomarker S100-beta in monitoring the response of malignant melanoma. In such melanomas, melanocytes , the cells that make pigment in our skin, produce the protein S100-beta in high concentrations dependent on the number of cancer cells.
Sarah, Duchess of York has been diagnosed with malignant melanoma following the removal of a cancerous mole during treatment for breast cancer. Melanoma is a type of skin cancer that can spread to ...
3D medical illustration depicting the TNM stages in breast cancer. Cancer staging can be divided into a clinical stage and a pathologic stage. In the TNM (Tumor, Node, Metastasis) system, clinical stage and pathologic stage are denoted by a small "c" or "p" before the stage (e.g., cT3N1M0 or pT2N0).
[67]: 29, 31 Even though it is much less common, malignant melanoma is responsible for 75% of all skin cancer-related deaths. [68] The survival rate for people with melanoma depends upon when they start treatment. The cure rate is very high when melanoma is detected in early stages, when it can easily be removed surgically.
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