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Corneal cross-linking (CXL) with riboflavin (vitamin B 2) and UV-A light is a surgical treatment for corneal ectasia such as keratoconus, PMD, and post-LASIK ectasia. It is used in an attempt to make the cornea stronger. According to a 2015 Cochrane review, there is insufficient evidence to determine if it is useful in keratoconus. [2]
In 2016, however, the FDA approved cross-linking surgery as a treatment for keratoconus and recommended that a registry system should be set-up to evaluate the long-term treatment effect. [ 9 ] [ 70 ] The Save Sight Keratoconus Registry is an international database of keratoconus patients that is tracking outcomes of cross-linking in patients ...
Keratoconus, a progressive, noninflammatory, bilateral, asymmetric disease, characterized by paraxial stromal thinning and weakening that leads to corneal surface distortion. [2] Keratoglobus, a rare noninflammatory corneal thinning disorder, characterised by generalised thinning and globular protrusion of the cornea. [3]
[1] [2] Corneal transplantation is performed when medicines, keratoconus conservative surgery and cross-linking can no longer heal the cornea. This surgical procedure usually treats corneal blindness, [3] [4] with success rates of at least 41% as of 2021. [5] [6] [7]
Corneal topography showing stage II keratoconus. Computerized corneal topography can be employed for diagnostics. It is, in fact, one of the exams the patients have to undergo prior to the Cross-linking and the Mini Asymmetric Radial Keratotomy (M.A.R.K.).
There is evidence suggesting corneal collagen cross-linking may be beneficial for patients with pellucid marginal degeneration. [12] [13] [14] Research shows some promising results by combining collagen cross linking with photorefractive keratectomy, or with topography-guided transepithelial surface ablation. [7]
Hints and the solution for today's Wordle on Friday, December 13.
Cross-linking may refer to Cross-link , a chemical bond of one polymer chain to another Corneal collagen cross-linking , a parasurgical treatment for corneal ectasia and keratoconus