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Nortriptyline is an active metabolite of amitriptyline by demethylation in the liver. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it is classed as a first-generation antidepressant. [36] Nortriptyline may also have a sleep-improving effect due to antagonism of the H 1 and 5-HT 2A receptors. [37]
A 2017 review of research published in the journal Current Psychiatry Reports noted that it’s common for antidepressants to affect sleep, regardless of the type.
However, that may not be such a wise idea, as insomnia, a disorder that affects how you fall asleep, stay asleep, or a combination of the two, The 6 Biggest Risk Factors for Insomnia Skip to main ...
The Guardian reports that one of the genes impacted by PFAS is the cathepsin B gene, which can create enzymes, when in high levels, have in turn been linked to both sleep disorders and Alzheimer's ...
Sleep apnea, obstructive sleep apnea, obstruction of the airway during sleep, causing lack of sufficient deep sleep, often accompanied by snoring. Other forms of sleep apnea are less common. [ 89 ] Obstructive sleep apnea (OSA) is a medical disorder that is caused by repetitive collapse of the upper airway (back of the throat) during sleep.
Because serotonin and the related hormone melatonin are involved in promoting sleep, they counterbalance the wake-promoting action of increased catecholaminergic neurotransmission. This is accounted for by the lethargic feel that some SSRIs can produce, although TCAs and antipsychotics can also cause lethargy albeit through different mechanisms.
This isn’t the first time that better sleep has been linked with a lower risk of dementia: A study published in October even found that people with sleep apnea are more likely to develop dementia.
Additionally, lack of sleep causes increased anxiety-like behaviors and impairs the brain's ability to block out unimportant stimuli when performing tasks requiring attention. Disruptions in important brain circuits and the downregulation of proteins necessary for cognitive stability are the causes of these behavioral abnormalities. [ 30 ]