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  2. Effects of long-term benzodiazepine use - Wikipedia

    en.wikipedia.org/wiki/Effects_of_long-term...

    Because benzodiazepines in general may be associated with increased suicide risk, care should be taken when prescribing, especially to at-risk patients. [59] [60] Depressed adolescents who were taking benzodiazepines were found to have a greatly increased risk of self-harm or suicide, although the sample size was small. The effects of ...

  3. Somnifacient - Wikipedia

    en.wikipedia.org/wiki/Somnifacient

    The elderly should avoid the use of benzodiazepines due to the increased risk of cognitive impairment, falls and fractures. [18] Benzodiazepines are also contraindicated in pregnancy and breast-feeding women since they may cause floppy infant syndrome in infants, characterized by hypotonia and CNS depression. [16]

  4. Midazolam - Wikipedia

    en.wikipedia.org/wiki/Midazolam

    The toxicity of benzodiazepine overdose and the risk of death are also increased in the elderly and those with obstructive pulmonary disease or when used intravenously. Treatment is supportive; activated charcoal can be used within an hour of the overdose. The antidote for an overdose of midazolam (or any other benzodiazepine) is flumazenil. [41]

  5. Benzodiazepine - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine

    Benzodiazepines have been shown to upregulate microglial spine engulfment and prompt overzealous eradication of synaptic connections. [180] This mechanism may help explain the increased risk of dementia associated with long-term benzodiazepine treatment. [181] The benzodiazepine class of drugs also interact with peripheral benzodiazepine receptors.

  6. Benzodiazepine dependence - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine_dependence

    Failure to treat benzodiazepine dependence in the elderly can cause serious medical complications. [14] The elderly have less cognitive reserve and are more sensitive to the short (e.g., in between dose withdrawal) and protracted withdrawal effects of benzodiazepines, as well as the side-effects both from short-term and long-term use. This can ...

  7. Chlordiazepoxide - Wikipedia

    en.wikipedia.org/wiki/Chlordiazepoxide

    Chlordiazepoxide is generally considered an inappropriate benzodiazepine for the elderly due to its long elimination half-life and the risks of accumulation. [10] Benzodiazepines require special precaution if used in the elderly, pregnancy, children, alcohol- or drug-dependent individuals and individuals with comorbid psychiatric disorders. [11]

  8. Benzodiazepine use disorder - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine_use_disorder

    Benzodiazepine abuse is steadily increasing and is now a major public health problem. Benzodiazepine abuse is mostly limited to individuals who abuse other drugs, i.e. poly-drug abusers. Most prescribed users do not abuse their medication, however, some high dose prescribed users do become involved with the illicit drug scene.

  9. Diazepam - Wikipedia

    en.wikipedia.org/wiki/Diazepam

    [59] [60] The elderly metabolise benzodiazepines much more slowly than younger adults, and are also more sensitive to the effects of benzodiazepines, even at similar blood plasma levels. Doses of diazepam are recommended to be about half of those given to younger people, and treatment is limited to a maximum of two weeks.