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The major warnings include renal toxicity, infertility in males, and embryo/fetal harm. General side effects of this radioligand therapy include fatigue, nausea, dry mouth, anemia, decreased appetite, and constipation. Regular blood tests and imaging post-therapy are needed to see if the radioligand therapy is working and its side effects.
In both cases, the compound needs to accumulate in the target organ and any surplus compound present needs to clear the body rapidly. In medical diagnostic imaging, this then produces a clear diagnostic image (high image contrast), and in radiotherapy leads to an attack of the target (e.g. tumor) while minimizing side effects to non-target organs.
A radioactive tracer, radiotracer, or radioactive label is a synthetic derivative of a natural compound in which one or more atoms have been replaced by a radionuclide (a radioactive atom). By virtue of its radioactive decay , it can be used to explore the mechanism of chemical reactions by tracing the path that the radioisotope follows from ...
A radioactive tracer is injected through any accessible vein and then allowed to circulate to the liver, where it is excreted into the bile ducts and stored by the gallbladder [3] until released into the duodenum. Use of cholescintigraphic scans as a first-line form of imaging varies depending on indication.
Their work built upon earlier discoveries by Wilhelm Konrad Roentgen for X-ray, Henri Becquerel for radioactive uranium salts, and Marie Curie (mother of Irène Curie) for radioactive thorium, polonium and coining the term "radioactivity." Taro Takemi studied the application of nuclear physics to medicine in the 1930s. The history of nuclear ...
Positron emission tomography (PET) [1] is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption.
The Radiation Exposure Compensation Act (RECA), the quarter-century old law that compensates Americans sickened by U.S. nuclear testing, expired this summer, but two Native American women are ...
Sand containing gamma-emitting tracer isotopes is used to trace and measure fractures. [citation needed] A 1995 study found that radioactive tracers were used in over 15% of stimulated oil and gas wells. [109] In the United States, injection of radionuclides are licensed and regulated by the Nuclear Regulatory Commission (NRC). [110]