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The activated α subunit activates phospholipase C, which hydrolyzes membrane bound phosphatidylinositol 4,5-bisphosphate (PIP 2), resulting in the formation of secondary messengers diacylglycerol (DAG) and inositol-1,4,5-triphosphate (IP 3). [10] IP 3 binds to calcium pumps on ER, transporting Ca 2+, another second messenger, into the cytoplasm.
Another example, sonic hedgehog signaling pathway, is one of the key regulators of embryonic development and is present in all bilaterians. [2] Signaling proteins give cells information to make the embryo develop properly. When the pathway malfunctions, it can result in diseases like basal cell carcinoma. [3]
The pathway is especially important in red blood cells (erythrocytes). The reactions of the pathway were elucidated in the early 1950s by Bernard Horecker and co-workers. [2] [3] There are two distinct phases in the pathway. The first is the oxidative phase, in which NADPH is generated, and the second is the non-oxidative synthesis of
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events.Proteins responsible for detecting stimuli are generally termed receptors, although in some cases the term sensor is used. [1]
The citric acid cycle (Krebs cycle) is a good example of an amphibolic pathway because it functions in both the degradative (carbohydrate, protein, and fatty acid) and biosynthetic processes. [2] The citric acid cycle occurs on the cytosol of bacteria and within the mitochondria of eukaryotic cells.
The C1-complex is composed of 1 molecule of C1q, 2 molecules of C1r and 2 molecules of C1s, or C1qr 2 s 2. This occurs when C1q binds to IgM or IgG complexed with antigens. A single pentameric IgM can initiate the pathway, while several, ideally six, IgGs are needed. This also occurs when C1q binds directly to the surface of the pathogen.
Branched pathways have unique control properties compared to simple linear chain or cyclic pathways. These properties can be investigated using metabolic control analysis . The fluxes can be controlled by enzyme concentrations e 1 {\displaystyle e_{1}} , e 2 {\displaystyle e_{2}} , and e 3 {\displaystyle e_{3}} respectively, described by the ...
Cells with a defective G 2-M checkpoint will undergo apoptosis or death after cell division if they enter the M phase before repairing their DNA. [1] The defining biochemical feature of this checkpoint is the activation of M-phase cyclin-CDK complexes, which phosphorylate proteins that promote spindle assembly and bring the cell to metaphase. [2]