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SGLT2 is mainly expressed in the kidneys on the epithelial cells lining the first segment of the proximal convoluted tubule. By inhibiting SGLT2, gliflozins prevent the kidneys' reuptake of glucose from the glomerular filtrate and subsequently lower the glucose level in the blood and promote the excretion of glucose in the urine . [41] [42]
SGLT2 is a member of the sodium glucose cotransporter family, which are sodium-dependent glucose transport proteins. SGLT2 is the major cotransporter involved in glucose reabsorption in the kidney. [6] SGLT2 is located in the early proximal tubule, and is responsible for reabsorption of 80-90% of the glucose filtered by the kidney glomerulus. [7]
The low cost of most sulfonylureas, however, especially when considering their significant efficacy in blood glucose reduction, tends to keep them as a more feasible option in many patients - neither SGLT2 inhibitors nor GLP-1 agonists, the classes most favored by the AACE guidelines after metformin, are currently available as generics.
The ACC men's soccer tournament is the conference championship tournament in soccer for the Atlantic Coast Conference (ACC). The tournament has been held every year since 1987. It is a single-elimination tournament and seeding is based on regular season records.
Harris presided over the joint session of Congress for the certification. But the encounter between Bruce and Harris started to go viral days after it occurred.
The 2022 Atlantic Coast Conference football season, part of the 2022 NCAA Division I FBS football season, was the 70th season of college football played for the Atlantic Coast Conference (ACC). The ACC consisted of 14 members in two divisions.
The Atlantic Coast Conference (ACC) is a collegiate athletic conference located in the United States. Headquartered in Charlotte, North Carolina, the ACC's eighteen member universities compete in the National Collegiate Athletic Association (NCAA)'s Division I. ACC football teams compete in the NCAA Division I Football Bowl Subdivision. The ACC ...
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