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Enlarged goitres may extend beyond the normal position of the thyroid gland to below the sternum, around the airway or esophagus. [61] Goitres may be associated with hyperthyroidism or hypothyroidism, relating to the underlying cause of the goitre. [61] Thyroid function tests may be done to investigate the cause and effects of the goitre.
Thyroid hormone leads to heat generation in humans. However, the thyronamines function via some unknown mechanism to inhibit neuronal activity; this plays an important role in the hibernation cycles of mammals and the moulting behaviour of birds. One effect of administering the thyronamines is a severe drop in body temperature.
Thyroid follicular cells (also called thyroid epithelial cells or thyrocytes [1]) are the major cell type in the thyroid gland, and are responsible for the production and secretion of the thyroid hormones thyroxine (T 4) and triiodothyronine (T 3).
In humans, the major endocrine glands are the thyroid, parathyroid, pituitary, pineal, and adrenal glands, and the (male) testis and (female) ovaries. The hypothalamus, pancreas, and thymus also function as endocrine glands, among other functions. (The hypothalamus and pituitary glands are organs of the neuroendocrine system.
Thyroglobulin (Tg) is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Tg is secreted and accumulated at hundreds of grams per litre in the extracellular compartment of the thyroid follicles, accounting for approximately half of the protein content of the thyroid gland. [5]
Thyroid stimulating hormone (TSH) is produced by the pituitary gland, another hormone-producing organ in the head. This in turn causes the thyroid to produce T3 and T4, which play a role in the ...
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