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A Howell–Jolly body (marked by arrow) within an erythrocyte. A Howell–Jolly body is a cytopathological finding of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes. During maturation in the bone marrow, late erythroblasts normally expel their nuclei; but, in some cases, a small portion of DNA remains. The presence of ...
Micronuclei are also referred to Howell-Jolly bodies; discovered by hematologists William Henry Howell and Justin Marie Jolly in erythrocytes. Micronucleus induction by a chemical was first reported in Ehrlich ascites tumor cells treated with colchicine.
Howell-Jolly body-like inclusions (HJBLi) are a hematopathological finding of an inclusion arising from detached DNA nuclear fragment in white blood cells caused by dysplastic granulopoiesis. [1] The inclusion is aptly named for its similar appearance of the Howell–Jolly body in erythrocytes. [2] The term was coined in 1989. [2]
Howell-Jolly bodies: small, round fragments of the nucleus resulting from karyorrhexis or nuclear disintegration of the late reticulocyte and stain reddish-blue with Wright's stain. Basophilic stipplings – these stipplings are either fine or coarse, deep blue to purple staining inclusion that appear on a dried Wright's stain.
Howell–Jolly bodies are found on red blood cells and contain chromatin remnants from basophilic cells. [7] Under normal conditions, these nuclear remnants are removed from the blood by the spleen's filtering capabilities. Howell-Jolly bodies can be identified and quantified using a blood smear or by flow cytometry. [2]
Micronuclei in newly formed red blood cells in humans are known as Howell-Jolly bodies because these structures were first identified and described in erythrocytes by hematologists William Howell and Justin Jolly. These structures were later found to be associated with deficiencies in vitamins such as folate and B12.
For Siwar Derbeli a national rice shortage is not just another inconvenient symptom of Tunisia's stretched national finances but a source of hunger because the coeliac disease she suffers from ...
Peripheral blood smear in patient with thrombotic thrombocytopenic purpura. Typical schistocytes are annotated. A schistocyte or schizocyte (from Greek schistos for "divided" and kytos for "hollow" or "cell") is a fragmented part of a red blood cell.