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Porphyrin complexes of zinc have been known since the 1930s. [1] In 1974 ZPP was identified as a major non-heme porphyrin formed in red cells as the result of lead poisoning or iron deficiency., [8] It was already known at this time that non-heme protoporphyrin IX levels were elevated in these conditions, but prior investigators had used acidic extraction methods in their assays that converted ...
Most zinc is in the brain, muscle, bones, kidney, and liver, with the highest concentrations in the prostate and parts of the eye. [11] Semen is particularly rich in zinc, a key factor in prostate gland function and reproductive organ growth. [12] Zinc homeostasis of the body is mainly controlled by the intestine.
Naturally occurring zinc (30 Zn) is composed of the 5 stable isotopes 64 Zn, 66 Zn, 67 Zn, 68 Zn, and 70 Zn with 64 Zn being the most abundant (48.6% natural abundance).Twenty-eight radioisotopes have been characterised with the most stable being 65 Zn with a half-life of 244.26 days, and then 72 Zn with a half-life of 46.5 hours.
Most zinc is in the brain, muscle, bones, kidney, and liver, with the highest concentrations in the prostate and parts of the eye. [197] Semen is particularly rich in zinc, a key factor in prostate gland function and reproductive organ growth. [198] Zinc homeostasis of the body is mainly controlled by the intestine.
In some prostate cancers, PSMA is the second-most upregulated gene product, with an 8- to 12-fold increase over levels in noncancerous prostate cells. [19] Because of this high expression, PSMA is being developed as potential biomarker for therapy and imaging of some cancers. [ 20 ]
Radiopharmaceuticals emit radiation themselves, which is different from contrast media which absorb or alter external electromagnetism or ultrasound. Radiopharmacology is the branch of pharmacology that specializes in these agents. The main group of these compounds are the radiotracers used to diagnose dysfunction in body tissues.
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