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  2. Mitochondrial theory of ageing - Wikipedia

    en.wikipedia.org/wiki/Mitochondrial_theory_of_ageing

    The mitochondrial theory of ageing has two varieties: free radical and non-free radical. The first is one of the variants of the free radical theory of ageing. It was formulated by J. Miquel and colleagues in 1980 [1] and was developed in the works of Linnane and coworkers (1989). [2] The second was proposed by A. N. Lobachev in 1978. [3]

  3. Free-radical theory of aging - Wikipedia

    en.wikipedia.org/wiki/Free-radical_theory_of_aging

    Brewer proposed a theory which integrates the free radical theory of aging with the insulin signalling effects in aging. [36] Brewer's theory suggests "sedentary behaviour associated with age triggers an oxidized redox shift and impaired mitochondrial function". [36] This mitochondrial impairment leads to more sedentary behaviour and ...

  4. Outline of life extension - Wikipedia

    en.wikipedia.org/wiki/Outline_of_life_extension

    Cross-links. Crosslinking of DNA; Free radicals – atom, molecule, or ion that has unpaired valence electrons. With some exceptions, these unpaired electrons make free radicals highly chemically reactive towards other substances, or even towards themselves: their molecules will often spontaneously dimerize or polymerize if they come in contact with each other.

  5. Strategies for engineered negligible senescence - Wikipedia

    en.wikipedia.org/wiki/Strategies_for_Engineered...

    The term "engineered negligible senescence" first appeared in print in Aubrey de Grey's 1999 book The Mitochondrial Free Radical Theory of Aging. [8] De Grey defined SENS as a "goal-directed rather than curiosity-driven" [9] approach to the science of aging, and "an effort to expand regenerative medicine into the territory of aging". [10]

  6. Biogerontology - Wikipedia

    en.wikipedia.org/wiki/Biogerontology

    The free-radical theory of aging proposes that this damage cumulatively degrades the biological function of cells and impacts the process of aging. [18] The idea that free radicals are toxic agents was first proposed by Rebeca Gerschman and colleagues in 1945, [19] but came to prominence in 1956, when Denham Harman proposed the free-radical ...

  7. Today’s NYT ‘Strands’ Hints, Spangram and Answers for ...

    www.aol.com/today-nyt-strands-hints-spangram...

    According to the New York Times, here's exactly how to play Strands: Find theme words to fill the board. Theme words stay highlighted in blue when found.

  8. Life extension - Wikipedia

    en.wikipedia.org/wiki/Life_extension

    During the process of aging, an organism accumulates damage to its macromolecules, cells, tissues, and organs.Specifically, aging is characterized as and thought to be caused by "genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular ...

  9. Get orthopedic slide-on shoes up to 50% off during Cyber Monday

    www.aol.com/lifestyle/get-orthopedic-slide-on...

    Here are 10 pairs of hands-free shoes you can pick up tonight before the Cyber Monday deals end. ... This Olay anti-aging cream is down to $18: 'In one week, wrinkles are clearing' AOL.